hROR1/4T1
CBPG0072
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| I. Background | |||
| 受體酪氨酸激酶樣孤兒受體（Receptor Tyrosine Kinase-like orphan receptor，ROR）是 Ⅰ型受體酪氨酸激酶（receptor tyrosine kinase，RTK）家族中的成員，是一類膜受體，主要 包括 ROR1 和 ROR2。其中 ROR1 主要通過參與細(xì)胞內(nèi)與細(xì)胞間信號(hào)傳導(dǎo)，實(shí)現(xiàn)調(diào)節(jié)細(xì)胞 代謝、增殖、凋亡、分化、遷移、轉(zhuǎn)移等功能。ROR1 在正常組織中（除了原腸胚時(shí)期） 表達(dá)量較低，但 ROR1 在多種腫瘤細(xì)胞高度表達(dá)，包括乳腺癌、卵巢癌、腎癌、肺腺細(xì)胞 癌、胃癌等實(shí)體瘤細(xì)胞以及某些血液腫瘤細(xì)胞。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hROR1 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+2μg/ml Puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | |||
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Figure 1. Recombinant hROR1/4T1 stably expressing ROR1. |
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| V. In VIVO Data | |||
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Index |
Content |
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Animal |
BALB/C, 7weeks, female |
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Implanted Position |
Subcutaneous (right lower flank region ) |
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Injected Cell Numbers |
3×10^5/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hROR1/4T1 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3.hROR1/4T1 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
