hROR1/CT26
CBPG0073
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| I. Background | |
| 受體酪氨酸激酶樣孤兒受體（Receptor Tyrosine Kinase-like orphan receptor，ROR）是 Ⅰ型受體酪氨酸激酶（receptor tyrosine kinase，RTK）家族中的成員，是一類膜受體，主要 包括 ROR1 和 ROR2。其中 ROR1 主要通過參與細(xì)胞內(nèi)與細(xì)胞間信號(hào)傳導(dǎo)，實(shí)現(xiàn)調(diào)節(jié)細(xì)胞 代謝、增殖、凋亡、分化、遷移、轉(zhuǎn)移等功能。ROR1 在正常組織中（除了原腸胚時(shí)期） 表達(dá)量較低，但 ROR1 在多種腫瘤細(xì)胞高度表達(dá)，包括乳腺癌、卵巢癌、腎癌、肺腺細(xì)胞 癌、胃癌等實(shí)體瘤細(xì)胞以及某些血液腫瘤細(xì)胞。 | |
| II. Introduction | |
| Host Cell: | CT26 |
| Expressed gene: | hROR1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+10μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mouse |
| Tissue: | colon, metastatic |
| Morphology: | N/A |
| Growth Properties: | monolayer |
| IV. Representative Data | |
|
Figure 1. Recombinant hROR1/CT26 stably expressing ROR1. |
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| V. In VIVO Data | |
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Index |
Content |
|
Animal |
BALB/C, 6weeks, female |
|
Implanted Position |
Subcutaneous (right flank region ) |
|
Injected Cell Numbers |
5×10^5/0.1ml |
|
Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hROR1/CT26 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3.hROR1/CT26 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
