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ERBB Family Effector Reporter Cell

CBP74507

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I. Background
     N/A
 
II. Description
     N/A
 
III. Introduction
Expressed gene: ERBB
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640 +10%FBS + 100 μg/ml Hygromycin B
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
IV. Representative Data

Figure 1.  Recombinant ERBB Family Effector Reporter Cell stably expressing EGFR & ERBB2 & ERBB3.


Figure 2. Dose Response of Ligands in ERBB Family Effector Reporter Cell (C16).



Figure 3. Inhibition of Human NRG-β2 induced Reporter Activity by ERBB Family Small Molecular Inhibitor in ERBB Family Effector Reporter Cell (C16).


Figure 4. 
Inhibition of Human EGF induced Reporter Activity by ERBB Family Blocking Abs in ERBB Family Effector Reporter Cell(C16).




Figure 5. Inhibition of Human EGF induced Reporter Activity by ERBB Family Small Molecular Inhibitor in ERBB Family Effector Reporter Cell( C16).

 


Figure 6. Inhibition of Human NRG-β1 induced Reporter Activity by ERBB Family Blocking Abs in ERBB Family Effector Reporter Cell(C16).



Figure 7. Inhibition of Human NRG-β1 induced Reporter Activity by ERBB Family Small Molecular Inhibitor in ERBB Family Effector Reporter Cell (C16).



Figure 8. Inhibition of Human NRG-β2 induced Reporter Activity by ERBB Family Blocking Abs in ERBB Family Effector Reporter Cell(C16).

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