Hs746T/CR
CBP60481DR-2
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| I. Background | |
| Crizotinib 作為全球首個(gè)靶向 ALK/ROS1/MET 的多激酶抑制劑，顯著改善晚期 ALK 陽 性非小細(xì)胞肺癌（NSCLC）患者生存，但其耐藥機(jī)制主要涉及靶點(diǎn)二次突變（如 ALK L1196M 守門突變、G1202R 溶劑前沿突變直接阻礙藥物結(jié)合）、旁路信號(hào)激活 （EGFR/KIT 擴(kuò)增或 KRAS 突變驅(qū)動(dòng)替代通路）、藥代動(dòng)力學(xué)逃逸（血腦屏障穿透不足致 腦轉(zhuǎn)移進(jìn)展），以及下游信號(hào)重塑（如 STAT3/SFK 持續(xù)激活維持腫瘤生存）。 | |
| II. Introduction | |
| Host Cell: | Hs746T/CR |
| Culture Medium: | DMEM+10%FBS+500 nM Crizotinib |
| Gi50 on Hs746T： | 10.7nM |
| Gi50 on Hs746T/CR： | ＞1000nM |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | stomach; derived from metastatic site: left leg |
| Disease: | gastric carcinoma |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
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IV.Representative DATA |
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Figure 1. CTG Proliferation Assay of Hs746T CR (Crizotinib Resistant). |
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