hCLDN6(Claudin6)/MC-38
CBPG0050
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產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫
| I. Background | |||
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CLDNs 是上皮細胞緊密連接的主要成分。CLDN6 是緊密連接家族（CLDNs）的一 員，是一個四次跨膜蛋白，具有較短的胞質(zhì) N 端和 C 端胞質(zhì)結(jié)構(gòu)域、兩個胞外結(jié)構(gòu)域（較 大的 ECL1 和較小的 ECL2）和一個短的胞內(nèi)環(huán)。CLDN6 可參與乳腺癌、胃癌、肝細胞癌 等多種惡性腫瘤的發(fā)生發(fā)展。CLDN6 具有重要的生物學功能，其異常表達與丙型肝炎感染 有關(guān)。
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| II. Introduction | |||
| Host Cell: | MC-38 | ||
| Expressed gene: | hCLDN6(Claudin6) | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mus musculus, mouse | ||
| Tissue: | Colon | ||
| Morphology: | Epitheloid cell | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | ||
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Figure 1. Recombinant hCLDN6(Claudin6)/MC38 stably expressing CLDN6. |
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| V. In VIVO Data | ||
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Index |
Content |
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Animal |
C57BL/6J, 6weeks, female |
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Implanted Position |
Subcutaneous (right lower flank region ) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hCLDN6(Claudin6)/MC38 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3. hCLDN6(Claudin6)/MC38 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
