hCLDN6(Claudin6)/4T1
CBPG0048
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| I. Background | |||
| CLDNs 是上皮細(xì)胞緊密連接的主要成分。CLDN6 是緊密連接家族（CLDNs）的一員，是一個(gè)四次跨膜蛋白，具有較短的胞質(zhì) N 端和 C 端胞質(zhì)結(jié)構(gòu)域、兩個(gè)胞外結(jié)構(gòu)域（較大的 ECL1 和較小的 ECL2）和一個(gè)短的胞內(nèi)環(huán)。CLDN6 可參與乳腺癌、胃癌、肝細(xì)胞癌等多種惡性腫瘤的發(fā)生發(fā)展。CLDN6 具有重要的生物學(xué)功能，其異常表達(dá)與丙型肝炎感染有關(guān)。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hCLDN6(Claudin6) | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+2 μg/ml puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | |||
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Figure 1. Recombinant hCLDN6(Claudin6)/4T1 stably expressing CLDN6. |
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