cGAS-KO/NFκB-SEAP/THP-1
CBP74214
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| I. Background | |
| Cyclic guanosine monophosphate-adenosine monophosphate adenosine synthetase (cGAS) is a DNA sensor that detects and binds to cytosolic DNA to generate cyclic GMP-AMP (cGAMP). As a second messenger, cGAMP mainly activates the adapter protein STING, which induces the production of type I interferons (IFNs) and inflammatory cytokines.cGAS is extensively involved in the innate immune response, senescence, and tumor immunity, thereby exhibiting a tumor-suppressive function, most of which is mediated by the STING pathway. | |
| II. Introduction | |
| Host Cell: | THP-1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+ 2 mM L-glutamine+ 25 mM HEPES+ 10%FBS+ 100 µg/ml Normocin+ Pen-Strep (100 U/ml-100 µg/ml) |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | peripheral blood |
| Disease: | acute monocytic leukemia |
| Morphology: | monocyte |
| Growth Properties: | suspension |
| IV. Representative Data | |
